# Extracts from age-related glandular disorders Fluid and electrolyte imbalance: With age, the response to the antidiuretic hormone ADH increases, which causes a decrease in the kidney's ability to excrete water. Renal clearance decreases at a rate of 8 ml/min/1.73 m for every 10 years after the age of 30. The sensitivity of the kidney to aldosterone decreases with respect to Sodium may decrease or rise according to the controlling factor - blood sodium decreases often in hospitalized patients, those taking diuretics, and cancer patients Symptoms of hyponatraemia agitation, convulsions and lethargy - sodium increases in the elderly due to a weak sense of thirst where thirst is stimulated when plasma osmolality >292 ml osmol/kg Water, while at older ages it elicits with an osmolality higher than 296, so in any disturbance of consciousness in the elderly, do not forget to check blood electrolytes .. Stay safe